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DISCUSSION
Be sure to add the IP address of Mail Express to Internet Explorer's "Trusted sites" zone. When you access a local area network (LAN), an intranet share, or an intranet website, the share or website is considered to be in the "Internet Zone," which is assigned a "high security" level. By default, no websites are assigned to the Trusted Sites zone.
Refer to the Microsoft Support article How to use security zones in Internet Explorer for details of how to configure different levels of security for websites that you visit.